openTECR (Open database on Thermodynamics of Enzyme-Catalyzed Reactions) is a database and a community.

We aim to create a reliable, free, machine-actionable data collection of apparent equilibrium constants of enzyme-catalyzed reactions, with a clear change process to integrate new data and correct errors.

This database is expected to serve computational and experimental scientists in the fields of metabolic engineering, genome-scale metabolic modelling, biocatalysis and related fields by providing curated information. It is used by eQuilibrator and other applications as the shared data basis for their individual calculations.

In a first step towards a truly open database, we recurated an existing database with more than 5500 data points, representing the biggest catalog of measured thermodynamic parameters for biologically relevant reactions. This existing database, the Thermodynamics of Enzyme-Catalzyed Reactions Database (TECRDB), was originally created by the National Institute of Standards and Technology and published as a set of pdf files containing tables and metadata.

You can read more about our effort on TECRDB here.

Our community organizes openly using a Google Groups. To become part of the mailing list, visit https://groups.google.com/g/opentecr.

You can read more about next steps, our roadmap, and see our code at GitHub: https://github.com/opentecr.